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 The following chart indicates that with increased BMI there was an increase in the prevalence of type 2 diabetes, hypertension, and hypercholesterolemia. Fortunately, even modest weight loss reduces health risks. A sustained "weight loss as little as 5% to 10% has been shown to improve disorders associated with obesity."5,41,42,72 Even relatively modest decreases in weight in the obese can result in substantial health benefits. "Weight loss of 10% or less is often associated with marked clinical improvement."71 In fact, NAASO, NIH and WHO recommend weight loss for obesity-related disorders.41,42,72 
A possible explanation for improvements in blood glucose, blood pressure and lipids with modest weight loss is the finding that high-risk upper-body visceral fat is lost disproportionately versus subcutaneous fat in early weight reduction.64 Loss of visceral adipose tissue confers additional health benefits. In one study conducted in similarly obese women — one with a predominantly upper-body (UB) fat distribution, the other with a lower-body (LB) distribution — "weight loss was similar between groups (~8 kg), and no change occurred in lean body mass or basal metabolic rate." 32 However, cholesterol and triglycerides were greater (<0.01) in the UB group at baseline and decreased significantly more in these women (<0.01) than in the LB group.32 Weight loss with XENICAL plus diet significantly improves obesity-related risk factors.19 Such weight loss by obese patients is associated with:
Type 2 Diabetes Dyslipidemia Hypertension The long-term effects of XENICAL (orlistat) on morbidity and mortality associated with obesity have not been established. Managing Patients with Obesity-Related Comorbidities More about Obesity as a Clinical Condition | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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