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 Fortunately, even modest weight loss reduces health risks. A sustained "weight loss as little as 5% to 10% has been shown to improve disorders associated with obesity."5,41,42,72 Even relatively modest decreases in weight in the obese can result in substantial health benefits. "Weight loss of 10% or less is often associated with marked clinical improvement."71 In fact, NAASO, NIH and WHO recommend weight loss for obesity-related disorders.41,42,72 
A possible explanation for the rapidity with which morbidity declines with modest weight loss is the recent finding that high-risk upper-body visceral fat is lost disproportionately versus subcutaneous fat in early weight reduction.64 Loss of visceral adipose tissue confers additional health benefits. In one study of weight loss in otherwise comparable groups of obese women - one with a predominantly upper-body (UB) fat distribution, the other with a lower-body (LB) distribution - "weight loss was similar between groups (~8 kg), and no change occurred in lean body mass or basal metabolic rate." 32 However, cholesterol and triglycerides were greater (<0.01) in the UB group at baseline and decreased significantly more in these women (<0.01) than in the LB group.32 Weight loss with XENICAL plus diet significantly improves obesity-related risk factors.19 Such weight loss by obese patients is associated with:
Type 2 Diabetes Dyslipidemia Hypertension The long-term effects of orlistat on morbidity and mortality associated with obesity have not been established. Managing Patients with Obesity-Related Comorbidities More about Obesity as a Clinical Condition | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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